Rockstar parent company Take-Two Interactive told fans in this support forum thread that it is "happy for fans" to upload gameplay footage, but warns them that any videos containing spoilers and other "in-game entertainment" will be flagged for removal via a takedown notice to whatever service they might be using.
Take-Two says that videos showing the end of the game, pure cutscenes, or any other "big reveals" from the Grand Theft Auto V's story will be flagged for removal. Take-Two said it is OK to show cutscenes as part of a larger playthrough, but isolated cinematics revealing plot will be removed.
In addition, videos featuring in-game entertainment like TV shows or other performances will also be removed.
"We prefer fans to experience these in the context of the game's world," Take-Two said.
The company noted that it has the right to remove any content it finds "objectionable" on a case-by-case basis and to change its policy whenever it wishes. Questions about the policy can be directed at Take-Two via firstname.lastname@example.org.
The game officially launched on PS3 and Xbox 360 today.